Five novel prenylated xanthones from Resina Garciniae

Abstract

Fourteen prenylated xanthone derivatives were isolated from gamboge, the dry latex of Garcinia hanburyi, and their structures were elucidated by a detailed spectroscopic analysis. Five of them, isogambogenic acid (1), desoxymorellinin (2), 10-methoxygambogenic acid (3), 10-methoxygambogic acid (4) and 10-ethoxy gambogic acid (5), are new compounds. All of them showed potent cytotoxicity against HL-60, SMMC-7721 and BGC-83 cells.

Keywords:

• Resina Garciniae
• Guttiferae
• Prenylated xanthone
• Isogambogenic acid
• Desoxymorellinin
• 10-methoxygambogenic acid

Acknowledgements

This work was financially supported by the National High Technology Research and Development (863) Programme of China (No. 2002AA2Z3112) and Jiangsu Science and Technology Programme (No. BE2001618). Thanks are due to Dong Jun Chen, Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, for the NMR measurement.