Antibacterial constituents from Stemona sessilifolia

Abstract

Bioassay-guided fractionation led to the isolation of eight compounds from Stemona sessilifolia. Of the eight isolates, three new bibenzyls, stilbostemins M–O (1–3), and a new tocopherol, 6-methoxy-3,4-dehydro-δ-tocopherol (4) were revealed together with four known compounds 3,5-dihydroxy-2′-methoxy bibenzyl (5), 3,5-dihydroxy bibenzyl (6), β-tocopherol (7), and γ-tocopherol (8). Compounds 5, 6, and 8 exhibited strong antibacterial activities against Staphylococcus aureus and S. epidermidis.

Keywords:

• Stemona sessilifolia
• Stilbenoids
• Tocopherols
• Antibacterial activities

Acknowledgements

This work was supported by a grant from Hi-Tech Research and Development Program of China (2004AA2Z3302).