A potent anti-HIV polyphenol from Salvia yunnanensis

Abstract

A new polyphenol, designated as salvianolic acid N, was isolated from the aqueous extracts of the roots of Salvia yunnanensis. Its chemical structure was elucidated as 3-(3,4-dihydroxylphenyl)-2-{(E)-3-(1,8,9-trihydroxyl-dibenzo[b,f]oxpin-3-yl)acryloxloxy}propanoic acid (1) on the basis of NMR and MS spectral analyses. The new polyphenol inhibited both HIV-1 IN in vitro and also reduced HIV-1 p24 antigen in MT-4 cell lines.

Keywords:

• Salvia yunnanensis
• Labiatae
• salvianolic acid N
• anti-HIV activity

Acknowledgements

The authors are grateful to Professor Li Lianniang, Institute of Materia Medica, Beijing, for her assistance on the structure elucidation of salvianolic acid N. This work was also supported by National High-Tech R&D Program (863 Program).