Three new flavanols from Daphne giraldii

Abstract

Three new flavanols, 5-p-hydroxybenzoxy-7-hydroxyl-8-ethoxycarbonyl-( − )-afzelechin (1), 5-p-hydroxybenzoxy-7-(2, 3, 5-trihydroxybenzoxy)-8-ethoxycarbonyl-( − )-afzelechin (2), and 5-p-hydroxybenzoxy-7-(2, 3, 5-trihydroxybenzoxy)-8-methoxycarbonyl-( − )-afzelechin (3), were isolated from Daphne giraldii Nitsche and their structures were elucidated by spectroscopic methods, especially by 2D-NMR and MS analyses.

Keywords:

• Daphne giraldii
• Thymelaeaceae
• flavanol
• afzelechin

Acknowledgements

This research was partially supported by the program for Changjiang Scholars and Innovative Research Team in University (PCSIRT), the National Science Foundation of China (No. 20402024), and the Scientific Foundation of Shanghai of China (Nos 03QMH1414, 04DZ19842, 04DZ19856, 04DZ19857, 05DZ19733, 06DZ19717, and 06DZ19005). The authors are grateful to Professor CeMing Tan for collecting and identifying the plant.