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Journal of Asian Natural Products Research Volume 10, 2008 - Issue 8
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Original Articles

Cytotoxic lanostanoid triterpenes from Ganoderma lucidum

Shu-Hong Guan Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Shanghai Research Center for TCM Modernization, Chinese Academy of Sciences, Shanghai, 201203, China
,
Jia-Meng Xia Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Shanghai Research Center for TCM Modernization, Chinese Academy of Sciences, Shanghai, 201203, China
,
Min Yang Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Shanghai Research Center for TCM Modernization, Chinese Academy of Sciences, Shanghai, 201203, China
,
Xiao-Ming Wang Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Shanghai Research Center for TCM Modernization, Chinese Academy of Sciences, Shanghai, 201203, China
,
Xuan Liu Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Shanghai Research Center for TCM Modernization, Chinese Academy of Sciences, Shanghai, 201203, China
&
De-An Guo Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Shanghai Research Center for TCM Modernization, Chinese Academy of Sciences, Shanghai, 201203, ChinaCorrespondence[email protected]
Pages 695-700 | Received 28 Apr 2007, Accepted 25 Jul 2007, Published online: 07 Aug 2008
 
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Abstract

Two new lanostanoid triterpenes, 23S-hydroxy-3,7,11,15-tetraoxo-lanost-8,24E-diene-26-oic acid (1), and 12β-acetoxy-3β-hydroxy-7,11,15,23-tetraoxo-lanost-8,20E-diene-26-oic acid (16), together with 17 known compounds, were isolated from the fruit bodies of Ganoderma lucidum. Their structures were established by spectroscopic methods, especially 2D-NMR and MS analyses and by comparison with literature data. The cytotoxic assay of the above compounds against p388, Hela, BEL-7402, and SGC-7901 human cancer cell lines showed their cytotoxicity with the IC50 values in the range of 8–25 μm.

Acknowledgements

This work was supported by the National Natural Science Foundation of China (30701077).

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