Antifungal stilbenoids from Stemona japonica

Abstract

Three new dihydrostilbenes, stilbostemins P–R (1–3), and a new dihydrophenanthrene, stemanthrene G (4), were isolated from the roots of Stemona japonica together with three known bibenzyls, 3,5-dihydroxy-2′-methoxy bibenzyl (5), 3,3′-dihydroxy-2,5′-dimethoxy bibenzyl (6), and 3,5,2′-trihydroxy-4-methyl bibenzyl (7). Their structures were elucidated by spectroscopic analyses. Compounds 5 and 6 exhibited strong antifungal activities against Candida albicans.

Keywords:

• Stemona japonica
• stilbenoids
• stilbostemins P–R
• stemanthrene G
• antifungal

Acknowledgements

This work was supported by a grant from Hi-Tech Research and Development Program of China (2004AA2Z3302).