164
Views
2
CrossRef citations to date
0
Altmetric
Original Articles

The synthesis and biological evaluation of 10-O-dialkylaminoethyl ginkgolide B as platelet-activating factor antagonist

, , &
Pages 989-992 | Received 27 Feb 2008, Accepted 06 May 2008, Published online: 11 Nov 2008
 

Abstract

Four nitrogen-containing derivatives of ginkgolide B were synthesized to improve the physical–chemical properties and bioavailability of ginkgolide B. The reaction was accomplished with the nitrogen atom as neighboring group participating in the replacement reaction. All of the four compounds were proved to have excellent inhibiting effect on rabbit platelet aggregation induced by platelet-activating factor which is as well as ginkgolide B.

Acknowledgements

This work was partially supported by the Undergraduate Student Scientific and Innovation Foundation of the School of Pharmacy, Fudan University, Republic of China (KC200622).

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 426.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.