Two new piperidine alkaloids from the leaves of Microcos paniculata

Abstract

Two new piperidine alkaloids, microcosamines A (1) and B (2), were isolated from the leaves of Microcos paniculata. Their structures were elucidated by spectroscopic analysis. Both new compounds showed significant larvicidal activity against Culex quinquefasciatus.

Keywords:

• piperidine alkaloids
• Microcos paniculata
• larvicidal activity
• microcosamine A
• microcosamine B

Acknowledgements

We thank Mr Ruiqiang Chen, Guangzhou Institute of Chemistry, Chinese Academy of Sciences, for 1D- and 2D-NMR spectroscopic measurements. This work was supported by Guangdong Provincial Department of Science and Technology, China (2005B30101014).