Two new protoberberine quaternary alkaloids from Corydalis yanhusuo

Abstract

Two new protoberberine quaternary alkaloids, 13-methyl-palmatrubine (1) and 13-methyl-dehydrocorydalmine (2), were isolated from the tubers of Corydalis yanhusuo W.T. Wang. 1 was isolated as a natural product for the first time, and 2 a new compound. Their structures were elucidated on the basis of spectroscopic evidence, especially 1D- and 2D-NMR experiments.

Keywords:

• Corydalis yanhusuo
• protoberberine alkaloids
• 13-methyl-palmatrubine
• 13-methyl-dehydrocorydalmine

Acknowledgements

This work was supported by a grant from special fund for the basic scientific research business of the state-level scientific research institute of public welfare, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College. The authors thank the Analytical Center, Institute of Materia Medica Chinese Academy of Medical Sciences, and Peking Union Medical College for recording HR-ESI-MS. We are also thankful to the Beijing Institute of Microchemistry for recording NMR spectra.