A new compound, brefeldin A formylate, from Penicillium sp. strain HLKG-44

Abstract

A novel compound named as brefeldin A formylate (1), together with two known compounds, brefeldin A (2) and ergosterol (3), was isolated from the Penicillium sp. strain HLKG-44, which was isolated from polluted environment in Fujian Province. Their structures were identified based on the spectral and X-ray crystallographic analyses. The compound 1, brefeldin A formylate, exhibited moderate cytotoxic activity against the human lung cancer cell line A549 with IC₅₀ value of 18.9 μg/ml by the MTT assay protocol.

Keywords:

• Penicillium
• brefeldin A formylate
• crystal structure

Acknowledgements

The authors would like to thank the financial support from the National Natural Science Foundation of China (No. 20572061), Foundation of Xiamen University (No. 0070Z03134), and the National Natural Science Foundation of China (No. 20732004).