Abstract
Two new fatty acid derivatives, 9Z,12Z,15Z-octadecatrienoic acid sorbitol ester (1) and (10,11,12)-trihydroxy-(7Z,14Z)-heptadecadienoic acid (2), were isolated from the pollen of Brassica campestris L. var. oleifera DC., along with the four known fatty acid derivatives, 9Z,12Z,15Z-octadecatrienamide, N-(2-hydroxyethyl) (3), hexadecanoic acid sorbitol ester (4), 15,16-dihydroxy-9Z,12Z-octadecadienoic acid (5), and 9Z,12Z,15Z-octadecatrienoic acid 2,3-dihydroxypropyl ester (6). Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR as well as HR-ESI-MS experiments. All compounds were tested using a noncellular aromatase assay, and the results showed that some compounds possessed strong inhibitory activity.
Acknowledgements
This work was supported by the Natural Science Foundation of Shanghai Commission of Science and Technology (No. 06ZR14078), which was gratefully acknowledged.