A new cytotoxic homoisoflavonoid from Dracaena cambodiana

Abstract

A new homoisoflavonoid, named cambodianol (1), together with the two known flavanes, (2S)-7,3′-dihydroxy-4′-methoxy-8-methylflavane (2) and (2R)-7,4′-dihydroxy-8-methylflavane (3), were isolated from the stems of Dracaena cambodiana. Their structures were determined based on HR-ESI-MS and spectroscopic techniques (UV, IR, 1D-, and 2D-NMR). Compound 1 exhibited significant cytotoxic activities against K562 and SGC-7901 with the IC₅₀ values of 1.4 and 2.9 μg/ml, respectively.

Keywords:

• Dracaena cambodiana
• Agavaceae
• homoisoflavonoid
• cytotoxicity
• cambodianol

Acknowledgements

This research was financially supported by National Basic Research Program of China (2007CB116306) and National Programs for High Technology Research and Development of China (2007AA021504).