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Journal of Asian Natural Products Research Volume 11, 2009 - Issue 3
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Original Articles

Triterpenes from Astilbe chinensis

Jun-Yi Hu School of Pharmaceutical Sciences, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, China; School of Chemical Engineering, University of Science and Technology Liaoning, Anshan, Liaoning, China
,
Zhi Yao Department of Immunology, Tianjin Medical University, Tianjin, China
,
Ying-Qian Xu School of Chemical Engineering, University of Science and Technology Liaoning, Anshan, Liaoning, China
,
Yoshihisa Takaishi Faculty of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan
&
Hong-Quan Duan School of Pharmaceutical Sciences, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, ChinaCorrespondence[email protected]
Pages 236-242 | Received 02 Sep 2008, Accepted 26 Nov 2008, Published online: 30 Apr 2009
 
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Abstract

Six new triterpenes, 3β,6β-dihydroxyurs-12-en-27-oic acid (1), 3β,6β,24-trihydroxyurs-12-en-27-oic acid (2), 3β,6β,7α-trihydroxyurs-12-en-27-oic acid (3), 3β-acetoxy-6β-hydroxyurs-12-en-27-oic acid (4), 3β,6β,24-trihydroxyolean-12-en-27-oic acid (5), and 3β,6β,7α-trihydroxyolean-12-en-27-oic acid (6), were isolated from the rhizomes of Astilbe chinensis. Their structures were elucidated on the basis of 1D- and 2D-NMR analyses and HR-MS experiments. The isolated compounds exhibited significant cytotoxic activities against the SK-N-SH and HL-60 cell lines.

Acknowledgements

This project was supported by the grants from the Scientific Research Foundation, Tianjin Medical University, Tianjin, and the Postdoctoral Science Foundation of China (No. 20070410546).

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