Abstract
By introducing octyloxy to C-3 and alkyl groups to C-8 of jatrorrhizine, a series of 3-octyloxy-8-alkyljatrorrhizine derivatives were synthesized and their antimicrobial activities were evaluated in vitro. The results indicated that the derivatives exhibited high antimicrobial activities, especially against Gram-positive bacteria. The 3-octyloxy-8-butyljatrorrhizine displayed the highest antimicrobial activity in all compounds. Their structure–activity relationships were discussed.
Acknowledgements
This work was supported by the National Natural Science Foundation of China (20673084), the Natural Science Foundation Project of CQ CSTC (2008BB5257), and the Key Technologies R&D Program of CQ CSTC (2008AA5021).