Six new cycloartane triterpene glycosides from Actaea asiatica

Abstract

Six new cycloartane triterpene glycosides, (3′,12β)-O-diacetyl-cimigenol-3-O-β-d-xylopyranoside (1), (4′,25)-O-diacetyl-cimigenol-3-O-β-d-xylopyranoside (2), 2′-O-acetyl-25-O-methyl-cimigenol-3-O-β-d-xylopyranoside (3), 2′-O-acetyl-25-O-ethyl-cimigenol-3-O-β-d-xylopyranoside (4), 3′-O-acetyl-cimicifugoside (5), and 4′-O-acetyl-23-epi-26-deoxycimifugoside (6), were isolated from the rhizomes of Actaea asiatica. Their structures were elucidated on the basis of chemical methods and spectroscopic analysis. Compounds 1, 2, 4–6 exhibited positive cytotoxic activities.

Keywords:

• Ranunculaceae
• Actaea asiatica
• cycloartane triterpene glycosides
• cytotoxic activities

Acknowledgement

The project was sponsored by the Scientific Research Foundation of Tianjin Medical University.