Constituents from the seeds of Brucea javanica with inhibitory activity of Tobacco mosaic virus

Abstract

Three new constituents were obtained along with 10 known compounds from the seeds of Brucea javanica. The structures of these compounds were determined based on spectral and chemical evidence. These new compounds included a monoterpenoid glycoside and two sesquiterpenes. Bioactivity screening of these constituents showed that compounds 1, 3, 8, 9, and 13 with obvious activities in inhibiting multiplication of the Tobacco mosaic virus.

Keywords:

• Simaroubaceae
• Brucea javanica
• monoterpenoid glycoside
• sesquiterpene
• lignan
• Tobacco mosaic virus

Acknowledgements

This research was supported by the National Natural Science Foundation of China (Grant No. 30770089) and Fujian Administration of Education (Grant Nos 2006NZ0002C4, 2008J0073, and 2006F5017). We thank the staff of the analytical group of Department of Chemistry, Taiwan University for measurements of NMR and FAB-MS spectra.