Two new compounds from the roots of Ligusticum chuanxiong

Abstract

Two new compounds, named ligusticoside A (1), a novel phthalide derivative with a lactone ring, and 4-pentylcyclohex-3-ene-1α,2β-diol (2), were isolated from the rhizomes of Ligusticum chuanxiong. Their structures were determined by spectral methods (MS, IR, UV, 1D and 2D NMR). An X-ray diffraction experiment was performed to confirm the structure of compound 1.

Keywords:

• Ligusticum chuanxiong
• phthalide derivatives
• ligusticoside A
• 4-pentylcyclohex-3-ene-1α,2β-diol

Acknowledgements

The authors are grateful to the staff of the analytical group of State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, for measurements of all spectra, and to Prof. Ming-Jin Xie (Yunnan University) for his professional measurement of the X-ray diffraction. This work was supported by the Natural Science Foundation of Yunnan (No. 312007C090M), the External Cooperation Program of Chinese Academy of Sciences (No. GJHZ200818), and CAS-Croucher Foundation (CAS-CF07/08.SC03).