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Journal of Asian Natural Products Research Volume 11, 2009 - Issue 11
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Original Articles

Asphorodin, a potent lipoxygenase inhibitory triterpene diglycoside from Asphodelus tenuifolius

Muhammad Safder International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan
,
Muhammad Imran International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan
,
Rashad Mehmood International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan
,
Abdul Malik International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, PakistanCorrespondence[email protected]
,
Nighat Afza Pharmaceutical Research Center, PCSIR Karachi Laboratories Complex, Karachi, 75280, Pakistan
,
Lubna Iqbal Pharmaceutical Research Center, PCSIR Karachi Laboratories Complex, Karachi, 75280, Pakistan
&
Mehreen Latif Pharmaceutical Research Center, PCSIR Karachi Laboratories Complex, Karachi, 75280, Pakistan
 show all
Pages 945-950 | Received 18 May 2009, Accepted 28 Jul 2009, Published online: 04 Nov 2009
 
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Abstract

Asphorodin (1), a new diglycoside, has been isolated from the ethyl acetate-soluble fraction of Asphodelus tenuifolius. It showed significant inhibitory activity against the enzyme lipoxygenase in a concentration-dependent manner. The Lineweaver–Burk and Dixon plots indicated that the nature of inhibition was non-competitive.

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