Two new compounds from the broth of the marine fungus Penicillium griseofulvum Y19-07

Abstract

Two new compounds, 4-hydroxyphenethyl methyl succinate (1) and 4-hydroxyphenethyl 2-(4-hydroxyphenyl)acetate (2), were isolated from the EtOAc extract of the broth of the marine fungus Penicillium griseofulvum Y19-07. Five known compounds were also obtained in this study. The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopy and mass spectrometry. All of the isolates were evaluated for their scavenging properties toward the 2,2-diphenyl-1-picrylhydrazyl free radical by spectroscopic assays. Also, in the cytotoxicity assay of the two new compounds against HL-60 and PC-3 prostate cancer cell lines, compound 2 showed potential activity with an IC₅₀ value of 64.5 μM against human HL-60 cancer cells.

Keywords:

• Penicillium griseofulvum
• marine fungus
• cytotoxicity

Acknowledgements

This work was supported by the Ministry of Science and Technology of China ‘Hi-Tech Research and Development Program of China’ (863 project), under Contract No. 2007AA09Z435, and ‘the National Natural Science Foundation of China’ under Contract No. 40776098.