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Original Articles

Three new eudesmanoids from the Formosan soft coral Nephthea erecta

, , , &
Pages 967-973 | Received 12 Jun 2009, Accepted 25 Aug 2009, Published online: 04 Nov 2009
 

Abstract

Chemical investigations on the organic extract of the Formosan soft coral Nephthea erecta led to the isolation of two new eudesmanoids, (4R*,5S*,6Z,10R*)-8-oxo-eudesm-6-en-5α,11-diol (1) and (6E,10R )-4,5-dioxo-11-methoxy-eudesm-6-ene (2), together with one new tri-nor-eudesmane sesquiterpenoid, (4S*,5E,10R*)-7-oxo-tri-nor-eudesm-5-en-4β-ol (3). The structures of metabolites 13 were elucidated through extensive spectroscopic analyses and by comparison with those reported in the literature. The anti-inflammatory activity using RAW 264.7 macrophages and their cytotoxicity against selected cancer cells of 13 were evaluated in vitro.

Acknowledgements

Financial support was provided by the National Science Council, Taiwan (NSC96-2320-B-110-003-MY3) awarded to C.-Y.D.

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