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Original Articles

Macagigantin, a farnesylated flavonol from Macaranga gigantea

, , , &
Pages 929-932 | Received 29 Apr 2009, Accepted 01 Sep 2009, Published online: 04 Nov 2009
 

Abstract

A new farnesylated flavonol derivative, macagigantin (1), together with two known flavonoids, glyasperin A (2) and apigenin (3), had been isolated from the acetone extract of the leaves of Macaranga gigantea. The structure of the new compound was elucidated as 6-farnesylkaempferol based on its spectroscopic data, including UV, IR, 1D and 2D NMR, and HR-EI-MS spectra. Compounds 13 were evaluated for their cytotoxic properties against P-388 cells, their IC50 values being 11.3, 6.0, and 5.1 μM, respectively.

Acknowledgements

The authors are grateful for the financial support from the office of the Ministry of National Education, Republic of Indonesia (Hibah Pasca Grant VII 2009). We also thank Associate Prof. E.L. Ghisalberti, the University of Western Australia, for mass spectra measurements.

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