Two new compounds from the marine Nigrospora sphaerica

Abstract

Two new compounds, 1-(5-oxotetrahydrofuran-2-yl)ethyl 2-phenylacetate (1) and 3-hydroxybutan-2-yl 2-hydroxy-3-phenylpropanoate (2), along with three known compounds, harzialactone A (3), benzeneethanol 4-hydroxy-1-acetate (4), and 1,4-dioxane-2,5-dione-3,6-bis(penylmethyl)-homopolymer (5), have been isolated from the fungus Nigrospora sphaerica. Their structures were determined on the basis of chemical and spectroscopic methods.

Keywords:

• Nigrospora sphaerica
• fungus
• 3-hydroxybutan-2-yl 2-hydroxy-3-phenylpropanoate
• 1-(5-oxotetrahydrofuran-2-yl)ethyl 2-phenylacetate

Acknowledgements

This research work was financially supported by the Ministry of Science and Technology ‘863’ project of China (Project Nos 2007AA09Z413 and 2007AA09Z435) and the National Natural Science Foundation (Project No. 20872094).