Synthesis and α-glucosidase inhibitory activity of oleanolic acid derivatives

Abstract

Glucosidations of oleanolic acid (1) and its dihydroxy-olide derivatives (2) were carried out to provide eight glycosides. All synthesized compounds were evaluated by in vitro α-glucosidase inhibitory activity assay. 3-Acetyl dihydroxy-olide oleanolic derivative 15 showed the most potent inhibitory effect. Structure–activity relationships within these compounds are discussed.

Keywords:

• oleanolic acid
• glycosides
• α-glucosidase
• inhibition ratio

Notes

^1. [email protected]

^2. [email protected]

^3. [email protected]

^4. [email protected]

Additional information

Notes on contributors

Shan Qian

1. 1. [email protected]

Jiao Hai Li

2. 2. [email protected]

Yu Wei Zhang

3. 3. [email protected]

Xin Chen

4. 4. [email protected]