Three new compounds from the marine fungus Penicillium sp.

Abstract

Continuous research on the ethyl acetate extract of the fermentation broth of the marine fungus Y26-02 (Penicillium sp.) led to the purification of one known and three new compounds. Their structures were elucidated, respectively, as butyl 2-(4-oxo-5,6-dihydro-2H-pyran-3-yl) acetate (1), 4-hydroxyphenethyl 2-(4-oxo-5,6-dihydro-2H-pyran-3-yl) acetate (2), 3-hydroxybenzyl 2-(4-oxo-5,6-dihydro-2H-pyran-3-yl) acetate (3), and desoxypatulinic acid (4) on the basis of their spectroscopic and physico-chemical properties.

Keywords:

• Clerodendrum inerme
• desoxypatulinic acid
• Penicillium sp.
• marine fungus

Acknowledgements

This work was supported by the Ministry of Science and Technology ‘863’ project of China under contract Nos 2007AA09Z413, 2007AA09Z435 and the National Natural Science Foundation of China under contract No. 40776098.