Two new xanthones from Artocarpus obtusus

Abstract

Two new xanthones, pyranocycloartobiloxanthone A (1) and dihydroartoindonesianin C (2), were isolated from the stem bark of Artocarpus obtusus Jarrett by chromatographic separation. Their structures were determined by using spectroscopic methods and comparison with known related compounds. Pyranocycloartobiloxanthone A (1) showed strong free radical scavenging activity by using DPPH assay as well as cytotoxicity towards K562, HL-60, and MCF7 cell lines.

Keywords:

• Artocarpus obtusus
• Moraceae
• pyranocycloartobiloxanthone A
• dihydroartoindonesianin C
• cytotoxicity

Acknowledgements

We wish to thank Universiti Putra Malaysia for providing laboratory facilities; the Malaysian Government for providing a research grant under Intensification of Research in Priority Areas (IRPA) Program; and one of us (NH) wishes to thank Universiti Sains Malaysia for granting study leave.