Synthesis and Anti-Proliferative Activity of Novel Quinolin-8-ol Derivatives

Abstract

Through the coupling of substituted benzaldehydes with 8-hydroxy 5-amino methyl quinoline scaffold, a series of new derivatives has been synthesized. In vitro growth inhibitory effects on cancer cell line model have been evaluated. Discussion on the chemical reactivity of these new polycyclic aromatic analogs to generate alkylating species led to the hypothesis that the presence of an imine moiety impedes the formation of quinone methide intermediate and consequently abolishes in part their antiproliferative activity.

Key Words:

• 8-hydroxyquinoline
• antiproliferative activity
• quinone methide

Acknowledgments

IBDML-CNRS (Institut de Biologie du Développement de Marseille-Luminy, France) is greatly acknowledged for financial support. N.G received financial support from the Programme franco-algérien de formation supérieure (PROFAS).