Abstract
A simple and efficient cerium(III) chloride -catalyzed procedure for the synthesis of 2-aryl or alkyl substituted quinazolinones from the condensation and oxidative cyclization of 2-aminobenzamide with aldehydes was reported. The reaction was carried out in the green solvent dimethyl carbonate in the presence of 5 mol% of CeCl3at 100°C under air and gave the corresponding quinazolinone derivatives in high yield.
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Acknowledgments
The authors are grateful to Nanjing University of Science and Technology and Yancheng Textile Vocational Technology College for financial support.