One-Pot Synthesis of Spiro[chromeno[2,3-c]pyrazole-4,3′-indoline]-diones Using Sulfonic Acid Functionalized Nanoporous Silica SBA-Pr-SO₃H and Study of Their Antimicrobial Properties

ABSTRACT

A novel and clean one-pot synthesis of spiro[chromeno[2,3-c]pyrazole-4,3′-indoline]-2′,5(6H)-diones via cyclocondensation reaction of isatins, 1,3-cyclohexadiones, and pyrazolone in aqueous media using SBA-Pr-SO₃H (sulfonic acid-functionalized mesoporous silica) as an efficient heterogeneous solid acid catalyst was reported. The antimicrobial activities of synthesized compounds have been tested.

KEYWORDS:

• 1,3-cyclohexadiones
• antimicrobial activity
• functionalized SBA-15
• isatin
• pyrazolone
• Spiro[chromeno[2,3-c]pyrazole-4,3′-indoline]-diones

Acknowledgments

Authors are thankful to the Research Council of Alzahra University and University of Tehran for the financial support for this work.