Abstract
In the present study, a green and versatile approach for the synthesis of a variety of 2-amino-3-cyano-4H-pyrans is reported via multicomponent reaction of aldehydes, malononitrile, and CH-acids including, 4-hydroxycoumarin, 3-methyl-1-phenyl-2-pyrazoline-5-one or ethyl acetoacetate/hydrazine hydrate. The reaction is properly progressed with taking advantage of extract of E. angustifolia leaves as a safe and natural catalyst. Moreover, the introduced approach is featured by mild reaction condition, short reaction time, simple work-up, and easy purification of products as well as avoiding the use of toxic solvents.
Graphical Abstract
Acknowledgments
We gratefully appreciate the financial support from the Research Council of University of Sistan and Baluchestan.