Nano Structured Bi₂O₃ Catalyzed Synthesis of 3-Phenyl-[1,2,4]Triazolo[3,4-a]Phthalazines and Their Cross-coupling Reaction Under Aqueous Conditions

Abstract

A novel and an expeditious approach for the synthesis of 3-phenyl-[1,2,4]triazolo[3,4-a]phthalazine derivatives has been achieved from 1,4-dichlorophthlazine and benzohydrazides in the presence of nano Bi₂O₃ catalyst. 3-Phenyl-[1,2,4]triazolo[3,4-a]phthalazines undergo substitution reaction with various –OH group to produce 6-substituted-3-phenyl-[1,2,4]triazolo[3,4-a]phthalazines in excellent yields under aqueous condition in the presence of Pd(OAc)₂, BINAP and nano Bi₂O₃ catalyst. The present protocol tolerates various functional groups and represents a reliable and time efficient method.

Graphical Abstract

Keywords:

• Aqueous condition
• nano Bi₂O₃
• phthlazine
• triazole

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

We are grateful to the financial support from the Department of Science and Technology – Science and Engineering Research Board (DST-SERB), India, under Fast Track Young Scientist Scheme in the form of major research project (No. SB/FT/CS-028/2013 dated: 09.06.2014, 24.09.2015, and 12.09.2016).