An Efficient, Microwave-Assisted, One-Pot Synthesis of Fluorinated 2,5-Disubstituted 1,3,4-Oxdiazole Derivative

Abstract

Efficient, rapid, and green procedure has been developed for the synthesis fluorinated 2,5-disubstituted 1,3,4-oxdiazoles using one-pot reaction of isoniazid or nicotic acid hydrazide and different fluorinated acid in the presence of ceric ammonium nitrate in PEG-400 as a solvent under microwave irradiation. The synthesized compounds were characterized by ¹H NMR, ¹³C NMR, IR, and mass spectra. The yields are good to excellent, the process is rapid. The protocol was shown to have some advantageous such as short reaction time, low cost, eco-friendly catalyst, and mild reaction conditions.

Keywords:

• 1,3,4-oxdiazole
• CAN
• isoniazid
• nicotinic acid hydrazide
• microwave irradiation
• PEG-400

Acknowledgments

The authors are thankful to Principal, Maulana Azad College, Aurangabad and Principal, Swami Vivekananda College, Mantha for providing the laboratory facility. We also thank SAIF Punjab University, Chandigarh and SAIF Shillong for providing the spectral and analytical data.

Disclosure statement

No potential conflict of interest was reported by the authors.