Abstract
Efficient, rapid, and green procedure has been developed for the synthesis fluorinated 2,5-disubstituted 1,3,4-oxdiazoles using one-pot reaction of isoniazid or nicotic acid hydrazide and different fluorinated acid in the presence of ceric ammonium nitrate in PEG-400 as a solvent under microwave irradiation. The synthesized compounds were characterized by 1H NMR, 13C NMR, IR, and mass spectra. The yields are good to excellent, the process is rapid. The protocol was shown to have some advantageous such as short reaction time, low cost, eco-friendly catalyst, and mild reaction conditions.
Acknowledgments
The authors are thankful to Principal, Maulana Azad College, Aurangabad and Principal, Swami Vivekananda College, Mantha for providing the laboratory facility. We also thank SAIF Punjab University, Chandigarh and SAIF Shillong for providing the spectral and analytical data.
Disclosure statement
No potential conflict of interest was reported by the authors.