Abstract
A novel and effective photochemical approach for access to 2-substituted pyrido[2,3-d]pyrimidines is described starting from the corresponding 2-(2-aminopyridin-3-yl)ethenol through a palladium-catalyzed reaction. Our strategy involves an original procedure under UV light as source of energy with reaction times of 24–36 h and yields ranging between 42 and 92%.
Graphical Abstract
Acknowledgment
The authors would like to thank the College of Pharmacy at Prince Sattam Bin Abdulaziz University for providing the necessary facilities to carry out this research work.