Synthesis of Pyrano[2, 3-d]Pyrimidine-2,4(3H)-Dione Derivatives Based-on Curcumin Using NiCo₂O₄@OCMC@Zn(BDC) Nanocomposite as a Novel and Efficient Catalyst

Abstract

Curcumin, a category of phenolic compound derivatives from the base of Curcuma longa (Zingiberaceae), represent a variety of beneficial effects on health and on events that succor in hampering certain diseases. The present research explains an efficient procedure for the synthesis of pyrano[2,3-d] pyrimidine-2,4(3H)-diones in high yields and short response times via a three-ingredient reaction of curcumin, aromatic aldehydes and 1,3-dimethylbarbituric acid in the presence of NiCo₂O₄@OCMC@Zn(BDC) nanocomposite. The catalyst was determined by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), Fourier transform infrared, (FT-IR) X-ray powder diffraction (XRD) and Brunauer–Emmett–Teller (BET). Moreover, the NiCo₂O₄@OCMC@Zn(BDC) catalyst can be recovered and reused several times without significant loss of its activity.

Keywords:

• Curcumin
• MOF
• multi-component reactions
• NiCo₂O₄@OCMC@Zn(BDC)
• pyrano[2,3-d]pyrimidine-2,4(3H)-diones

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The author gratefully acknowledges the financial support of this work by the Research Affairs Office of the Islamic Azad University, Qom Branch, Qom, I. R. Iran [grant number 2016-13929].