An Environment-Friendly Method for Green Synthesis of Pyranopyrazole Derivatives Catalyzed by CoCuFe₂O₄ Magnetic Nanocrystals under Solvent-Free Conditions

Abstract

An efficient and rapid four component reaction of ethyl acetoacetate, hydrazine hydrate, malononitrile and different aldehydes at environmentally benign room temperature and solvent free conditions. This research has developed for synthesis of pyranopyrazole derivatives in the presence of CoCuFe₂O₄ magnetic nanocrystals as reusable catalyst. The catalyst prepared and characterized by FT-IR, XRD, SEM, EDX and VSM techniques. The products confirmed by spectroscopic and physical data such as; melting points, FT-IR and ¹H NMR analyses.

Keywords:

• Green synthesis
• magnetic nanocrystal
• malononitrile
• pyranopyrazole
• solvent-free

Additional information

Funding

The authors are grateful to University of Kashan for supporting this work by Grant No. 159148/82.