Synthesis of Novel Pyrazolyl-1,3,4-Thiadiazole Analogues

Abstract

In the present study, we have designed a novel series of pyrazolyl-1,3,4-thiadiazole analogues by accommodating 1,3,4-thiadiazole ring at C – 4 of pyrazole ring with and without an amide linkage; 5-methyl-1,3-diphenyl-N-(5-phenyl-1,3,4-thiadiazol-2-yl)-1H-pyrazole-4-carboxamide and 2-(5-methyl-1,3-diphenyl-1H-pyrazol-4-yl)-5-phenyl-1,3,4-thiadiazole respectively. We have designed this class of heterocycles by keeping a wide audience in mind, which augment their scientific knowledge. Newly synthesized compounds were characterized by ¹H NMR, ¹³C NMR, mass, IR spectral studies. Single crystal X-ray analysis of some compounds also gave insight into the structural information.

Graphical Abstract

Keywords:

• Amide linkage
• pyrazole
• Lawesson’s reagent
• X-ray crystallography
• 134-thiadiazole

Acknowledgments

Dr. Shridevi is grateful to the CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Thiruvananthapuram for providing the necessary facility to carry out the research work.

Disclosure statement

There are no conflicts of interest.