The Microwave Assisted and Efficient Synthesis of 2-Substituted Benzimidazole Mono-Condensation of O-Phenylenediamines and Aldehyde

Abstract

Synthesis of 2-substituted benzimidazole derivatives using reactants aldehyde, o-phenylenediamine, and sodium hypophosphite as a catalyst using microwave irradiation. An efficient and green synthesis carried out using sodium hypophosphite gives high yield in shorts reaction time. This route provides key advantages such as high yield, clean, easy work-up, readily available catalyst, and good yield. Compared with the conventional method, microwave irradiation process has more advantages.

Keyword:

• Aldehyde
• benzimidazole
• green
• o-phenylenediamine
• sodium hypophosphite

Acknowledgments

The authors gratefully acknowledge the constant encouragement and support of the Head, Department of chemistry, Dr. BAMU Aurangabad. Principal, Deogiri College, Aurangabad. We are also thankful SAIF Panjab University Chandigarh and SAIF Lucknow.

Disclosure statement

The authors have declared that no conflict of interest exists.

Scheme 1. One pot synthesis of 2-substituted Benzimidazole using catalyst SHP from various aldehydes.