One-Pot Synthesis and Antioxidant Properties of Highly Substituted Piperidine Derivatives Promoted by Choline Chloride/Urea

Abstract

The simple pseudo four-component reaction of 2,7-naphthalenediol, tow molecules of aldehydes and ammonum carboxylates to produce a series of N-acylated and non-acylated highly substituted piperidine derivatives has been carried out in the presence of choline chloride/urea at 80 °C. One-pot reaction, high efficiency, appropriate reaction time, and easy purification of products by simple recrystallization are some of the considerable advantages of this procedure. The produced highly substituted piperidine derivatives were screened for their antioxidant property. The results indicated that the highly substituted piperidine derivative 4h had higher antioxidant properties.

Keywords:

• 2,7-naphthalenediol
• choline chloride/urea
• highly substituted piperidine
• one-pot reaction
• pseudo four-component reaction

Disclosure statement

There are no conflicts of interest.

Additional information

Funding

Financial support by Rasht Branch, Islamic Azad University Grant is gratefully acknowledged.