Facile Synthesis of Polyfunctional Indole-Pyrido[2,3-d]Pyrimidine Hybrids Using Nickel-Incorporated Fluorapatite Encapsulated Iron Oxide Nanocatalyst and Study of Their Antibacterial Activities

Abstract

Fe₃O₄@FAp@Ni was synthesized and has been used as a new and efficient recyclable magnetic nanocatalyst for the synthesis of polyfunctional indole-pyrido[2,3-d]pyrimidine hybrids. The Fe₃O₄@FAp@Ni was conveniently separated by an external magnet and could be reused at least six times without any appreciable change in catalytic activity. This novel protocol furnished the products in high to excellent yield (75–95%) and short reaction time. The antibacterial properties of the products were also evaluated and some of them exhibited promising activities.

Graphical Abstract

Keywords:

• Antibacterial activity
• Fe₃O₄@FAp@Ni
• indole
• magnetic nanocatalyst
• pyrido[23-d]pyrimidine

Disclosure statement

There are no conflict of interest.

Additional information

Funding

Partial financial support of University of Guilan for this research work is acknowledged.