An Efficient Synthesis of Phthalimides and Their Biological Activities

Abstract

Practical and efficient synthesis of phthalimides compounds 3 were described and characterized. The synthesized compounds were screened for their antimicrobial activities against gram-positive bacterial strains (Micrococcus luteus, Listeria monocytogenes, Staphylococcus aureus and Bacillus cereus), a gram-negative bacterial strain (Salmonella typhimurium) and a fungus (Candida albicans). Cytotoxicity studies of the of phthalimides 3 were conducted in two human cancer cell lines, MDA-MB-231 and MCF-7.

Keywords:

• phthalimides
• Antimicrobial
• Anticancer activities

Acknowledgements

This work was funded by the Research Supporting Project (RSP2020/75), King Saud University, Riyadh Saudi Arabia.