Copper-Free, Pd(OAc)₂ and Ruphos Catalyzed, C_sp²-C_sp Bond Formation of Tautomerizable Quinolinones

Abstract

An efficient Pd(OAc)₂ catalyzed, C_sp²-C_sp bond formation through tautomerizable quinolinones by reacting with different alkynes furnished alkynyl quinolines in excellent yields. The C-OH bond activation is facilitated by using BOP reagent in the presence of Ruphos/THF/H₂O system under copper-free aqueous conditions, which yields chemo-selectivity and could be a greater synthetic utility.

Graphical Abstract

Keywords:

• Copper-free
• Pd(OAc)2 Ruphos catalyzed
• Csp2-Csp
• tautomerizable quinolinones

Acknowledgements

The authors wish to express their gratitude to the VIT, Vellore, India for Major Research Initiative Program support and facilities and SIF-VIT for their support of NMR, GCMS and IR facilities.