Novel Tricyclic 2-Alkoxy-8-methyl-6-(pyrrolidin-1-yl)-4H-[1,2,4]triazolo[5,1-f]purine Derivatives: Synthesis and Characterization

Abstract

A convenient approach for the synthesis of diversely functionalized [1,2,4]triazolo[5,1-f]purine heterocyclic framework have been accomplished. The products were obtained through the combination of 5-amino-3-(methylthio)-1H-1,2,4-triazole with 5-bromo-2,4-dichloro-6-methylpyrimidine followed by a S_NAr alkoxylation of the novel tricyclic heterocyclic core with various aliphatic alcohols. All newly synthesized heterocycles were fully elucidated by both computational and spectral evaluations.

Keywords:

• [1,2,4]Triazolo[5,1-f]purine
• 5-amino-3-(methylthio)- 1H-1,2,4-triazole
• 5-bromo-2,4-dichloro-6-methylpyrimidine
• computational evaluations
• heterocyclization

Additional information

Funding

The authors gratefully acknowledge the Research Council of Ferdowsi University of Mashhad for financial support of this project (3/44470).