Design and Rapid Microwave Irradiated One-Pot Synthesis of Tetrahydropyrimidine Derivatives and Their Screening In Vitro Antidiabetic Activity

Abstract

A rapid and efficient method has been developed for one-pot synthesis of some newly designed tetrahydropyrimidine derivatives with aid of 1,3,4-oxadiazole containing aldehyde, substituted acetoacetanilide and thiourea/guanidine in the occurrence of microwave irradiation. The significant yield of products, atom economy, less time consuming, and catalyst-free synthesis were considered preferences of microwave irradiation. All synthesized compounds were characterized by ¹H NMR, ¹³C NMR, IR, and mass spectrometry techniques. All synthesized compounds were evaluated bioassay for in vitro antidiabetic screening viz α-amylase inhibition strategy and checked their potency against standard reference drug acarbose.

Keywords:

• Biginelli
• polycyclic aldehyde
• tetrahydropyrimidine
• antidiabetic
• microwave irradiation

Acknowledgements

The authors are thankful to the Department of chemistry, School of science, RK University (Rajkot) for providing laboratory facilities and National Facility for Drug Discovery (NFDD) for providing spectral data.

Disclosure statement

No potential conflict of interest was reported by the authors.

Scheme 2. Microwave assisted one-pot synthesis of 1,3,4-oxadiazole-based THPMs.