Abstract
Magnetized distilled water (MDW), as a green solvent, was used in the Hantzsch four-component synthesis of polyhydroquinolines and the three-component synthesis of 1,4-dihydropyridine condensation reactions of 1,3-cyclohexanedione/dimedone, ethyl acetoacetate/malononitrile, aldehydes, and ammonium acetate under catalyst-free conditions. The developed synthetic technique offers numerous advantages including eco-friendly, simplicity, low-costs, short reaction times, high reaction yields, and easy work-up compared to the traditional synthetic method. Moreover, the reaction rates were followed spectrophotometrically by monitoring the changes in the absorption spectrum of the reaction mixture in ordinary distilled water (ODW) and MDW. Also, the effect of magnetization time and the memory effect were studied.
Acknowledgment
We gratefully acknowledge the financial support of the Research Council of the Shahrood University of Technology. Also, the authors declare no conflicts of interest.