Antitubercular, Antimalarial Activity and Molecular Docking Study of New Synthesized 7-Chloroquinoline Derivatives

Abstract

We have synthesized a new series of 7-chloroquinoline derivatives by a single step choro-amine coupling reaction. Compounds 3a–l was tested for in vitro antitubercular and antimalarial agent. Compounds 3a and 3 b were more active than rifampicin against M. tuberculosis H37Rv and compound 3a was more active against P. falciparum strain as compared to quinine. Furthermore, compounds 3b and 3c were found to possess excellent activity as compared to quinine. These compounds could be considered as a new broad spectrum antitubercular and antimalarial agent. All the synthesized compounds were confirmed by IR, Mass, ¹HNMR and ¹³C NMR spectroscopy. Molecular docking studies were also done subsequently, using target, shikimate kinase (2IYZ) and hypoxanthine-guanine phosphoribosyltransferase (1BZY) enzyme to find the structural requirement for activity for these series of compounds.

Keywords:

• Chloroquinoline derivatives
• antitubercular
• antimalarial
• molecular docking

Acknowledgements

The authors express their sincere thanks to the Department of Chemistry, Sardar Patel University for providing research facilities. We are also thankful to DST, New Delhi for the assistance in general and for the PURSE central facility for mass spectrometry. We thank Dr Dhanji P. Rajani, Microcare Laboratory, Surat, Gujarat, India for the biological screening of the compounds reported herein.