An Efficient Synthetic Method for the Synthesis of Novel Pyrimido[1,2-a]pyrimidine-3-carboxylates: Comparison of Microwave and Conventional Heating

Abstract

A very simple and efficient procedure for the synthesis of novel pyrimido[1,2-a]pyrimidine derivatives is described. Thermal cyclization reactions of 2-aminopyrimidine and its substituted derivatives with diethyl ethoxymethylenemalonate (EMME) have been investigated. Conventional heating and microwave irradiation (MW) conditions were applied to enable the comparison of both techniques on the obtained products. Besides the effect of different reaction parameters and the substituents on the conversion reactions have been also investigated in detail. Structural analyses of all compounds synthesized with high yields have been carried out by suitable spectroscopic methods (FT-IR, NMR, mass spectroscopy, LC-MS TOF).

Graphical Abstract

Keywords:

• Pyrimido[1,2-a]pyrimidine
• 2-aminopyrimidine
• multicomponent reactions
• microwave assisted reactions
• quinolones antibiotics

Disclosure statement

No potential conflict of interest was reported by the authors.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

Mustafa Güllü and Duygu Bayramoğlu acknowledge here the support provided by AU-BAP [15L0430001].