A Convergent One-Pot Synthesis of Novel Pyrrole-Pyridopyrimidines Hybrids Using 1-Carboxymethyl-2,3-Dimethylimidazolium Iodide {[cmdmim]I} as a Recyclable Catalyst

Abstract

In this study, some novel pyridopyrimidines were synthesized via one-pot three-component reaction of 6-amino-N,N-dimethyluracil, 3-(1-methyl-1H-pyrrol-2-yl)-3-oxopropanenitrile and aromatic aldehydes in DMF under reflux conditions in the presence of 1-carboxymethyl-2,3-dimethylimidazolium iodide {[cmdmim]I} as a catalyst. The present procedure shows several advantages such as short reaction times, high yields, simple work-up and use of non-expensive and nontoxic materials. All products were characterized by spectroscopic (FT-IR, ¹H and ¹³C NMR) analyses.

Graphical Abstract

Keywords:

• 1-carboxymethyl-23-dimethylimidazolium iodide

Acknowledgments

We are thankful to the Research Council of University of Guilan for the partial support of this work.

Disclosure statement

No potential conflict of interest was reported by the author(s).