Abstract
In this study, some novel pyridopyrimidines were synthesized via one-pot three-component reaction of 6-amino-N,N-dimethyluracil, 3-(1-methyl-1H-pyrrol-2-yl)-3-oxopropanenitrile and aromatic aldehydes in DMF under reflux conditions in the presence of 1-carboxymethyl-2,3-dimethylimidazolium iodide {[cmdmim]I} as a catalyst. The present procedure shows several advantages such as short reaction times, high yields, simple work-up and use of non-expensive and nontoxic materials. All products were characterized by spectroscopic (FT-IR, 1H and 13C NMR) analyses.
Graphical Abstract
Acknowledgments
We are thankful to the Research Council of University of Guilan for the partial support of this work.
Disclosure statement
No potential conflict of interest was reported by the author(s).