New Potential Antitumor Pyrimidine Derivatives: Synthesis and Cytotoxicity Evaluation

Abstract

A new series of pyrimidine derivatives are reported here as antitumor agents such as pyrimidine carboxamide linked to thiophene, pyrazole, and thiazole moieties have been synthesized from the readily available (2-cyano-N-(5-cyano-2-phenyl-6-arylpyrimidin-4-yl)acetamide (6a,b). All the new compounds were screened for their antitumor activity in vitro against a panel of three human tumor cell lines namely, hepatocellular carcinoma (liver) HepG2, colon cancer HCT-116, and mammary gland breast MCF-7. Compounds 9b, 10b, 11b, and 19b displayed a significant therapeutic activity. All the synthesized new compounds were established their structures by means of spectroscopic analysis.

Graphical Abstract

Keywords:

• Anti-tumor
• cyanoacetamide
• pyrane
• pyridine

Acknowledgments

Author is grateful to Prof. Dr. Ahmed A Fadda (Ph.D, D.Sc) Professor of organic chemistry, faculty of science, Mansoura, Egypt for suggesting the point of research and his valuable discussion.

Disclosure statement

No potential conflict of interest was reported by the author(s).