Abstract
The Biginelli reaction is a one pot multicomponent reaction involves aromatic aldehyde, β-keto ester, and urea or thiourea in presence cationic exchange resins Purolite CT275DR supplied by Purolite to afford the corresponding dihydropyrimidine-2-one and there sulfur analog 3,4-dihydropyrimidine-2-thione in solvent free condition gave high yield and catalyst could be recycle and reused without much decrease in the catalytic activity.
Graphical Abstract
![](/cms/asset/9af5fc69-78d7-4f7c-a282-35e0a6febefb/gpol_a_1984262_uf0001_c.jpg)
Acknowledgments
The authors are thankful to Research Centre, Maulana Azad College Aurangabad, 431001, India for providing laboratory facility and also to Navin Fluorine International Limited, Dewas, Madhya Pradesh 455001, India for the analytical support.
Disclosure statement
No potential conflict of interest was reported by the author(s).